Probiodrug Licenses the TBA 2.1 Transgenic Alzheimer’s Disease Mouse Model to QPS Austria Neuropharmacology

HALLE/SAALE, Germany, GRAMBACH, Austria, 01 September 2015 – Probiodrug AG (Euronext Amsterdam: PBD), a biopharmaceutical company developing novel therapeutic solutions to treat Alzheimer’s disease (AD), has announced today an agreement to license the TBA2.1 tg Mouse to QPS Austria Neuropharmacology, a leading CRO for CNS drug development.

This mouse model has been developed, characterized and patented by Probiodrug (1,2). It has been used within the efforts to establish a new therapeutic concept of reducing brain pyroglutamate-modified Abeta (pGlu-Abeta) for the treatment of Alzheimer Disease. Licensing this model to QPS Austria Neuropharmacology makes it accessible to a wider community of academic and industry research groups.

Commenting on the announcement, Hans-Ulrich Demuth, co-founder and former CSO of Probiodrug, said: “Characterization and use of this model has been extremely useful for our understanding of the involvement of pGlu-Abeta in the initiation and progression of AD. This model is only one of a set of new AD-like models developed by Probiodrug to establish a comprehensive validation of pGlu-Abeta as a potential target to treat Alzheimer’s disease and to extensively profile potential drug candidates. I’m very pleased about the collaboration of Probiodrug with QPS to thereby offer our TBA2.1 mouse model to the wider AD and neurodegeneration research.”

Birgit Hutter-Paier, Director Neuropharmacology at QPS Austria added: “We are optimistic about this model being perfectly complementary to QPS’ current range of animal models for AD drug research. Transgenic animals are still among the most crucial tools to investigate drug candidates for the treatment of AD. The TBA2.1 mouse model will be a valuable addition to our portfolio of mouse models addressing the increasingly multifaceted APP pathology, which still has a prominent and highly relevant position in the field.”

As of today, Probiodrug has progressed two complementary strategies for tackling pGlu-Abeta with two medicine candidates in development: PQ912, a small molecule inhibitor of Glutaminyl Cyclase, now in phase 2, and PBD C06, a pGlu-Abeta-specific mAB in preclinical stage.

The TBA2.1 transgenic mouse model over-expresses pGlu-Abeta in neurons and is suitable to model neuronal loss and neurodegeneration, characteristics typical for disease progression. These mice represent the most rapid murine model of Abeta induced cognitive impairment, demonstrating the highly toxic nature of pGlu-Abeta.

1. Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation. Alexandru A, Jagla W, Graubner S, Becker A, Bäuscher C, Kohlmann S, Sedlmeier R, Raber KA, Cynis H, Rönicke R, Reymann KG, Petrasch-Parwez E, Hartlage-Rübsamen M, Waniek A, Rossner S, Schilling S, Osmand AP, Demuth HU, von Hörsten S. J Neurosci. 2011 Sep 7;31(36):12790-801. doi: 10.1523/JNEUROSCI.1794-11.2011
2. Patent:
   EP 2 195 336 B1
   US 8,283,517 B2

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For more information, please contact:

Probiodrug
Dr Konrad Glund, CEO,
Email: contact@probiodrug.de

Hume Brophy
Mary Clark, Supriya Mathur, Alexia Faure
Tel: +44 203440 5653
Email: probiodrug@humebrophy.com

QPS Austria
Koos Koops
Email: office-austria@qps.com

Birgit Hutter-Paier
Tel: +43 316 258111
Email: birgit.hutter-paier@qps.com

Notes to Editors:

About Probiodrug AG
Headquartered in Halle, Germany, Probiodrug AG (Euronext Amsterdam: PBD) is a biopharmaceutical company focused on the development of new therapeutic products for the treatment of Alzheimer’s disease.

Founded in 1997, the company successfully developed a novel therapeutic concept for diabetes – the DP4 inhibitors – which provided the basis for a novel class of antidiabetics – the gliptins. Its core capabilities are based on its long-standing expertise in the elucidation of the structure and function of enzymes involved in the modification of proteins and peptides, which play a central role in pathological conditions.

Today Probiodrug’s aim is to become a leading company in the development of Alzheimer’s disease treatments and to thereby provide a better life for Alzheimer’s disease patients. It has identified a new therapeutic concept linked to disease initiation and progression. The development approaches are targeting pyroglutamate-Abeta (pGlu-Abeta) as a therapeutic strategy to fight Alzheimer’s disease. The Company has medical use and composition of matter patents related to the inhibition of Glutaminyl Cyclase (QC) and anti-pGlu-Abeta- specific monoclonal antibodies, providing it, in the Company’s view, with a leading position in this field of research.

www.probiodrug.de

About QPS Austria
QPS Austria is a full-service contract research organization (CRO). The company performs preclinical as well as clinical research. The Neuropharmacology department focuses on drug development for neurodegenerative diseases. The profound expertise in neuroscience and more than a decade of experience in contract research result in a sustainable advantage for the customer. Validated transgenic & non-transgenic in vivo & in vitro models to address new as well as already established drug targets in neurodegenerative diseases are available.
The clinical research department offers clinical research services in all phases and indications. QPS’ clinical department is a small to medium-sized clinical CRO professionally addressing specific needs of the clients while being capable to translate expertise and experience into mono- and multicentric trials of different size due an impressive geographical coverage.

www.qps-austria.com

About Alzheimer’s disease
Alzheimer’s disease is a neurological disorder, which is the most common form of dementia, and ultimately leads to death. Because Alzheimer’s disease cannot be cured and is degenerative, the affected patients must increasingly rely on others for assistance. Today, 44 million people worldwide currently live with the condition and this number is expected to almost double by 2030 and to more than triple by 2050 to over 132 million. Alzheimer’s also has an estimated, global societal cost of over $600 billion (World Alzheimer Report 2014).

Forward Looking Statements
Information set forth in this press release contains forward-looking statements, which involve a number of risks and uncertainties. The forward-looking statements contained herein represent the judgment of Probiodrug AG and QPS Austria as of the date of this press release. Such forward-looking statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in these forward-looking statements. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any such statements to reflect any change in our expectations or any change in events, conditions or circumstances on which any such statement is based.