Probiodrug to Present at the 1st Meeting of The Society for CSF analysis and Clinical Neurochemistry

HALLE/SAALE, Germany, 11 May 2016 – Probiodrug AG (Euronext Amsterdam: PBD), a biopharmaceutical company developing novel therapeutic solutions to treat Alzheimer’s disease (AD), announces today that two posters will be presented at the 1st Meeting of the newly founded Society for CSF Analysis and Clinical Neurochemistry in Gothenburg, Sweden. The first general meeting will be held from 12 – 13 May, 2016 at the University of Gothenburg.

The posters being presented are entitled:

• “Quantitative Analysis of truncated Aβ peptide substrates of glutaminyl cyclase in human CSF samples using LC-MS/MS,” Antje Meyer, Matthias Orth, Torsten Hoffmann, Charlotte Teunissen, Inge Lues: presented by Dr Antje Meyer

• “Determination of Aβ Oligomers using a Flow Cytometry-Förster Resonance Energy Transfer (FRET) method,” Torsten Hoffmann, Radha Borrowdale, Martin Kleinschmidt, Markus Roucka, Christian Zafiu, Oliver Bannach, Thierry Pillot, Charlotte Teunissen, Inge Lues: presented by Dr Torsten Hoffmann

Probiodrug is evaluating and establishing new concept-related molecular biomarkers to be used in their ongoing Phase 2a study (SAPHIR). The emphasis is regarded as an important and key cornerstone in the read out hierarchy in clinical studies.

Dr Inge Lues, Chief Development Officer of Probiodrug, said: “The results being presented at the high calibre CSF Biomarker meeting are part of our comprehensive efforts to establish new biomarkers, respectively new biomarker assay techniques in the context of our pGlu-Abeta approach. These studies are pursued in close collaboration with various partners, especially with the VU Medical Center /Amsterdam.”

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For more information, please contact:

Probiodrug
Dr Konrad Glund, CEO
Email: contact@probiodrug.de

Hume Brophy
Supriya Mathur, Eva Haas, Alexia Faure
Tel: +44 (0) 207 862 64753
Email: probiodrug@humebrophy.com

The Trout Group
Tricia Truehart
Tel: +1 (646) 378-2953
Email: ttruehart@troutgroup.com

Notes to Editors:

About Probiodrug AG

Headquartered in Halle, Germany, Probiodrug AG (Euronext Amsterdam: PBD) is a biopharmaceutical company focused on the development of new therapeutic products for the treatment of Alzheimer’s disease.

Founded in 1997, the company successfully developed a novel therapeutic concept for diabetes – the DP4 inhibitors – which provided the basis for a novel class of antidiabetics – the gliptins. Its core capabilities are based on its long-standing expertise in the elucidation of the structure and function of enzymes involved in the modification of proteins and peptides, which play a central role in pathological conditions.

Today Probiodrug’s aim is to become a leading company in the development of Alzheimer’s disease treatments and to thereby provide a better life for Alzheimer’s disease patients. It has identified a new therapeutic concept linked to disease initiation and progression. The development approaches are targeting pyroglutamate-Abeta (pGlu-Abeta) as a therapeutic strategy to fight Alzheimer’s disease. The Company has medical use and composition of matter patents related to the inhibition of Glutaminyl Cyclase (QC) and anti-pGlu-Abeta- specific monoclonal antibodies, providing it, in the Company’s view, with a leading position in this field of research. www.probiodrug.de

About Alzheimer’s disease

Alzheimer’s disease is a neurological disorder, which is the most common form of dementia, and ultimately leads to death. Because Alzheimer’s disease cannot be cured and is degenerative, the affected patients must increasingly rely on others for assistance. Today, over 46 million people worldwide currently live with the condition and this number is expected to increase to 132 million by 2050. Alzheimer’s also has an estimated, global societal cost of US$ 818 billion (World Alzheimer Report 2015).

Forward Looking Statements

Information set forth in this press release contains forward-looking statements, which involve a number of risks and uncertainties. The forward-looking statements contained herein represent the judgment of Probiodrug AG as of the date of this press release. Such forward-looking statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in these forward-looking statements. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any such statements to reflect any change in our expectations or any change in events, conditions or circumstances on which any such statement is based.